A randomized, Phase 4, double-blind, placebo-controlled, 6-arm crossover study to investigate the systemic effect of lidocaine and ropivacaine when used for Transversus Abdominis Plane (TAP) blocks on hyperalgesia and pain perception in healthy volunteers aged 18 to 64 years.

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2025-520910-67-01

Enrollment

Registered

2026-05-28

Start date

Unknown

Completion date

Unknown

Last updated

2026-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute pain

Brief summary

Area of pinprick hyperalgesia induced by electrical stimulation

Detailed description

Pain intensity induced by electrical stimulation, Cuff-pressure pain tolerance threshold, Pain detection threshold tested by cuff-pressure algometry, Local anaesthetic plasma concentrations, Blood pressure, Heart rate, Subjective experience of LA side effects, Report of all adverse events

Interventions

DRUGROPIVACAINE

DRUGSODIUM CHLORIDE

DRUGLIDOCAINE HYDROCHLORIDE

Eligibility

Sex/Gender

Male

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Area of pinprick hyperalgesia induced by electrical stimulation	—

Secondary

Measure	Time frame
Pain intensity induced by electrical stimulation, Cuff-pressure pain tolerance threshold, Pain detection threshold tested by cuff-pressure algometry, Local anaesthetic plasma concentrations, Blood pressure, Heart rate, Subjective experience of LA side effects, Report of all adverse events	—

Outcome results

None listed

Source: EU CTIS · Data processed: May 29, 2026