CReep and maintenance flUid Salt ADministration rEduction in cRitically ill adultS - (CRUSADERS)

Conditions

Critically ill patients

Brief summary

The primary endpoint of the CRUSADERS study is Days alive and without life support (DAWOLS) at 90 days after ICU admission.

Detailed description

Occurrence of moderate and severe hyponatremia, Occurrence of moderate and severe hypernatremia, Occurrence of moderate and severe hyperchloremia, Fluid retention and diuretic use, Occurrence of hyperglycemia and hypoglycemia, Acute kidney injury, Mechanical ventilation, Mortality and length of stay, Daily and cumulative sodium, chloride and glucose administration: daily and cumulative sodium, chloride and glucose administration from all sources except for non-study fluid creep and oral intake. For blood products, estimated values of sodium and chloride content are used., Fluid balance: Daily and cumulative fluid balance on ICU days, excluding (calculations of) insensible losses. From the moment RRT or IV loop diuretics are started, fluid balance data are analyzed separately from the patients without those interventions. Fluid balance assessments are discontinued from the ICU day when the urinary catheter is removed or bladder irrigation is initiated.

Related papers

No related papers found yet.

Interventions

DRUGNatriumchloride 0

DRUG9 % w/v

DRUGViaflo

DRUGoplossing voor infusie

DRUGNaCl 0

DRUG3% w/v + Glucose 3

DRUG3% w/v Viaflo

DRUGoplossing voor intraveneuze infusie

DRUGGlucose 5 % w/v

DRUGPlasmalyte A Viaflo

DRUGoplossing voor infusie.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
The primary endpoint of the CRUSADERS study is Days alive and without life support (DAWOLS) at 90 days after ICU admission.	—

Secondary

Measure	Time frame
Occurrence of moderate and severe hyponatremia, Occurrence of moderate and severe hypernatremia, Occurrence of moderate and severe hyperchloremia, Fluid retention and diuretic use, Occurrence of hyperglycemia and hypoglycemia, Acute kidney injury, Mechanical ventilation, Mortality and length of stay, Daily and cumulative sodium, chloride and glucose administration: daily and cumulative sodium, chloride and glucose administration from all sources except for non-study fluid creep and oral intake. For blood products, estimated values of sodium and chloride content are used., Fluid balance: Daily and cumulative fluid balance on ICU days, excluding (calculations of) insensible losses. From the moment RRT or IV loop diuretics are started, fluid balance data are analyzed separately from the patients without those interventions. Fluid balance assessments are discontinued from the ICU day when the urinary catheter is removed or bladder irrigation is initiated.	—

Measure

Time frame

Occurrence of moderate and severe hyponatremia, Occurrence of moderate and severe hypernatremia, Occurrence of moderate and severe hyperchloremia, Fluid retention and diuretic use, Occurrence of hyperglycemia and hypoglycemia, Acute kidney injury, Mechanical ventilation, Mortality and length of stay, Daily and cumulative sodium, chloride and glucose administration: daily and cumulative sodium, chloride and glucose administration from all sources except for non-study fluid creep and oral intake. For blood products, estimated values of sodium and chloride content are used., Fluid balance: Daily and cumulative fluid balance on ICU days, excluding (calculations of) insensible losses. From the moment RRT or IV loop diuretics are started, fluid balance data are analyzed separately from the patients without those interventions. Fluid balance assessments are discontinued from the ICU day when the urinary catheter is removed or bladder irrigation is initiated.

—

Countries

Belgium

Outcome results

None listed