Cardiogenic shock
Conditions
Brief summary
- Change in blood lactate concentration measured as the difference between the maximum value at baseline: 0-1 hours after randomization and 72 hours after randomization, in the two treatment arms. - In case of death: change in blood lactate concentration measured as the difference between the maximum value at baseline: 0-1h after randomization and the last available lactate value from randomization, in the two treatment arms.
Detailed description
- death or need for ECMO/LVAD at 72 hours - death or need for ECMO/LVAD at discharge - change in SOFA score between baseline (0-1 hour from randomization) and 72 hours from randomization and between baseline (0-1 hour from randomization) and 7 days from randomization - lactate AUC (0-72 hours) - need for additional extra-trial inotrope at 72 hours
Interventions
DRUGDOBUTAMINE
Sponsors
Azienda Unita' Sanitaria Locale Toscana Sud Est
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Change in blood lactate concentration measured as the difference between the maximum value at baseline: 0-1 hours after randomization and 72 hours after randomization, in the two treatment arms. - In case of death: change in blood lactate concentration measured as the difference between the maximum value at baseline: 0-1h after randomization and the last available lactate value from randomization, in the two treatment arms. | — |
Secondary
| Measure | Time frame |
|---|---|
| - death or need for ECMO/LVAD at 72 hours - death or need for ECMO/LVAD at discharge - change in SOFA score between baseline (0-1 hour from randomization) and 72 hours from randomization and between baseline (0-1 hour from randomization) and 7 days from randomization - lactate AUC (0-72 hours) - need for additional extra-trial inotrope at 72 hours | — |
Countries
Italy
Outcome results
None listed