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TAILORED-PROM: TAILORED therapeutic regime in patients with preterm Premature Rupture Of Membranes to prolong pregnancy, improve maternal and neonatal outcomes, and reduce antibiotic burden

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-520237-77-00
Acronym
TAILORED-PROM
Enrollment
138
Registered
2025-04-17
Start date
2025-06-24
Completion date
Unknown
Last updated
2025-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm premature rupture of membrance in pregnancy.

Brief summary

The primary endpoint of the study is the latency of pregnancy of more than 7 days from premature rupture of membranes to delivery.

Detailed description

Latency to birth, Incidence of chorioamnionitis and funisitis, Short-term adverse maternal outcomes, Short-term neonatal outcomes, Microbiome in mother and newborn - optional outcome

Interventions

DRUGGENTAMICIN
DRUGCLARITHROMYCIN
DRUGDEXAMETHASONE
DRUGMAGNESIUM SULFATE

Sponsors

Vseobecna Fakultni Nemocnice V Praze
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
0 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
The primary endpoint of the study is the latency of pregnancy of more than 7 days from premature rupture of membranes to delivery.

Secondary

MeasureTime frame
Latency to birth, Incidence of chorioamnionitis and funisitis, Short-term adverse maternal outcomes, Short-term neonatal outcomes, Microbiome in mother and newborn - optional outcome

Countries

Czechia

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026