Cerebrospinal fluid circulation disorder seen in clinically suspected idiopathic normal pressure hydrocephalus
Conditions
Brief summary
Time-dependent change in signal intensity on brain MRI after intrathecal contrast administration will be analyzed with indicator dilution algorthim that will be optimized using computational fluid dynamic simulations., Registration of possible adverse events related to the intrathecal injection of Gadovist
Detailed description
Comparision between the distribution of the contrast and other MRI-sequences and cerebrospinal fluid dynamic parameters which provides us with information regarding possible driving mechanisms for the distribution., Quantified pre-operative glymphatic function will be correlated to clinical improvment after CSF shunting of INPH patients
Interventions
Sponsors
Region Vaesterbotten
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time-dependent change in signal intensity on brain MRI after intrathecal contrast administration will be analyzed with indicator dilution algorthim that will be optimized using computational fluid dynamic simulations., Registration of possible adverse events related to the intrathecal injection of Gadovist | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparision between the distribution of the contrast and other MRI-sequences and cerebrospinal fluid dynamic parameters which provides us with information regarding possible driving mechanisms for the distribution., Quantified pre-operative glymphatic function will be correlated to clinical improvment after CSF shunting of INPH patients | — |
Countries
Sweden
Outcome results
None listed