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A PilOt dose-escalation trial with EMP16 in preparation for Phase III – the POEM trial

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-520122-11-00
Acronym
EP-005
Enrollment
39
Registered
2025-04-22
Start date
2025-05-07
Completion date
2025-09-30
Last updated
2025-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Brief summary

The difference in total GITE1 score between EMP16 combined with Vi-Siblin® S and conventional orlistat combined with placebo dietary fibre supplement

Detailed description

Presence and participant rated severity of the individual GITE components: •oily spotting •faecal incontinence (including flatulence with discharge) •diarrhoea, Presence and Investigator-rated severity of GI-related AEs. all events jointly and individually, i.e. for: •oily spotting •faecal incontinence (including flatulence with discharge) •diarrhoea

Interventions

DRUGVi-Siblin S granulat
DRUGalli 60 mg hard capsules
DRUGDietary fibre supplement Placebo - Maltodextrin

Sponsors

Empros Pharma AB
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
The difference in total GITE1 score between EMP16 combined with Vi-Siblin® S and conventional orlistat combined with placebo dietary fibre supplement

Secondary

MeasureTime frame
Presence and participant rated severity of the individual GITE components: •oily spotting •faecal incontinence (including flatulence with discharge) •diarrhoea, Presence and Investigator-rated severity of GI-related AEs. all events jointly and individually, i.e. for: •oily spotting •faecal incontinence (including flatulence with discharge) •diarrhoea

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026