Depression
Conditions
Brief summary
Changes in the levels of peripheral inflammatory biomarkers in depressed patients before and after 8 weeks of treatment with Minocycline.
Detailed description
Changes in depressive symptoms in depressed patients before and after 8 weeks of treatment with Minocycline, Structural and functional brain changes before and after 8 weeks of treatment with Minocycline, Changes in the inflammatory status in the brain, in terms of microglia activation, before and after 8 weeks of treatment with Minocycline, Associations among changes in MRI, in microglia activation, peripheral inflammation and any improvement in depressive symptoms
Interventions
DRUG-
DRUGMINOCIN 100 mg capsule rigide
Sponsors
Provincia Lombardo Veneta Dell’Ordine Ospedaliero Di San Giovanni Di Dio Fatebenefratelli
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the levels of peripheral inflammatory biomarkers in depressed patients before and after 8 weeks of treatment with Minocycline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in depressive symptoms in depressed patients before and after 8 weeks of treatment with Minocycline, Structural and functional brain changes before and after 8 weeks of treatment with Minocycline, Changes in the inflammatory status in the brain, in terms of microglia activation, before and after 8 weeks of treatment with Minocycline, Associations among changes in MRI, in microglia activation, peripheral inflammation and any improvement in depressive symptoms | — |
Countries
Italy
Outcome results
None listed