Alzheimer's pathology, Maladie d' Alzheimer
Conditions
Brief summary
1) The topographic distribution regions of tau lesions, thanks to PET brain imaging using the 18F-AV-1451 as a ligand. 2) The correlation between the distribution of these tau lesions and: the cortical volume, the indices of integrity of the white matter bundles, the functional neural networks, as well as the reorganization of the "hubs" of these networks, thanks to the structural MRI, diffusion (MRI) and functional at rest (fMRI) imaging
Detailed description
Correlation between the concentration of tau and tau-phosphorylated proteins in cerebrospinal fluid (CSF) with the severity of hypometabolism measured by tau-PET. To establish this correlation the evaluation criterion is represented on one side by the cortico-cerebellar indices of fixation of the tau protein radioligand in PET, on the other side by the concentration of tau proteins in the CSF and tau-phosphorylated. Correlation between anatomical and functional connectivity.
Interventions
DRUG18F-AV-1451
Sponsors
Institut National De La Sante Et De La Recherche Medicale
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) The topographic distribution regions of tau lesions, thanks to PET brain imaging using the 18F-AV-1451 as a ligand. 2) The correlation between the distribution of these tau lesions and: the cortical volume, the indices of integrity of the white matter bundles, the functional neural networks, as well as the reorganization of the "hubs" of these networks, thanks to the structural MRI, diffusion (MRI) and functional at rest (fMRI) imaging | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between the concentration of tau and tau-phosphorylated proteins in cerebrospinal fluid (CSF) with the severity of hypometabolism measured by tau-PET. To establish this correlation the evaluation criterion is represented on one side by the cortico-cerebellar indices of fixation of the tau protein radioligand in PET, on the other side by the concentration of tau proteins in the CSF and tau-phosphorylated. Correlation between anatomical and functional connectivity. | — |
Countries
France
Outcome results
None listed