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Serotonin role on brain circuits involved in food avoidance in anorexia nervosa : Study of Gaze control and multimodal Brain imaging.

Status
Not yet recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-519848-33-00
Acronym
20CH240
Enrollment
75
Registered
2025-01-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa

Brief summary

BPND, the unit for measuring the non-displaceable binding potential of the [11C] DASB in PET imaging

Detailed description

Resting-state functional MRI measurement of cerebral blood flow quantified by ArterialSpin Labelling (ASL) to assess cerebral perfusion (regional cerebral blood flow)., Resting-state MRI measurement of water diffusion in white matter to assess structural brain connectivity structural brain connectivity, in DTI (diffusion tensor imaging) mode, Resting-state functional MRI measurement of white matter water Diffusion for the assessment of structural structural brain connectivity, in DTI (diffusion tensor imaging) mode, Functional MRI measurement of brain activity levels by BOLD in the resting state and during task performance simultaneously with PET acquisition, thanks to the hybrid PET-MRI CAMERA., The subjects' responses (subjective measures) to the various proposals made during the food choice and preference preferences., Avoidance and approach indices, as well as indices of time spent looking at items in different food categories, measured by tracking eye movements and gaze fixation on food items presented during food choice and preference tests (using a TOBII-type eye tracker)., Psychometric scales to characterize eating disorders and anxiety: EDI (Eating Disorder Inventory), DEBQ (Dutch Inventory), DEBQ (Dutch Eating Behavior Questionnaire), Spielberger Anxiety Scale (STAI), Beck Depression Scales, to measure and monitor subjects' depressive state which can be a confounding factor, since it is frequently since it is frequently associated with anxiety., Hormonal and nutritional parameters.

Interventions

DRUG3-AMINO-4-[2-[[METHYL((111C)METHYL)AMINO]METHYL]PHENYL]SULFANYLBENZONITRILE

Sponsors

Centre Hospitalier Universitaire De Saint Etienne
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
0 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
BPND, the unit for measuring the non-displaceable binding potential of the [11C] DASB in PET imaging

Secondary

MeasureTime frame
Resting-state functional MRI measurement of cerebral blood flow quantified by ArterialSpin Labelling (ASL) to assess cerebral perfusion (regional cerebral blood flow)., Resting-state MRI measurement of water diffusion in white matter to assess structural brain connectivity structural brain connectivity, in DTI (diffusion tensor imaging) mode, Resting-state functional MRI measurement of white matter water Diffusion for the assessment of structural structural brain connectivity, in DTI (diffusion tensor imaging) mode, Functional MRI measurement of brain activity levels by BOLD in the resting state and during task performance simultaneously with PET acquisition, thanks to the hybrid PET-MRI CAMERA., The subjects' responses (subjective measures) to the various proposals made during the food choice and preference preferences., Avoidance and approach indices, as well as indices of time spent looking at items in different food categories, measured by tracking eye movements and gaze fixation o

Countries

France

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026