AL amyloidosis, Cholangiocarcinoma, Chronic lymphocytic leukemia (CLL), deficient mismatch repair (dMMR) colorectal adenocarcinoma, deficient mismatch repair (dMMR) colorectal cancer, Esophageal squamous cell carcinoma, Follicular lymphoma, Gastric cardia cancer, Hepatocellular carcinoma, Hodgkin lymphoma, Locally advanced cutaneous squamous cell carcinoma, Melanoma, Myeloma, Non-small cell lung carcinoma, Pleural mesothelioma, Small cell lung carcinoma
Conditions
Brief summary
For each biotherapy studied, the maximum usable concentration considered non-irritant is defined as the maximum concentration that does not produce a skin reaction in at least 9 out of 10 patients (90% specificity) during skin testing.
Detailed description
A delayed reaction is considered if, at the intradermal injection sites, a skin reaction occurs 48 hours or one week after injection, or if a systemic reaction occurs following biotherapy administration. Patients will be contacted by phone to confirm the presence or absence of a delayed local reaction, and if necessary, a photograph taken during a consultation with the allergologist investigator or in a video consultation will confirm the reaction.
Interventions
DRUGATEZOLIZUMAB
DRUGDARATUMUMAB
DRUGNIVOLUMAB
DRUGDURVALUMAB
DRUGCEMIPLIMAB
DRUGOBINUTUZUMAB
DRUGPEMBROLIZUMAB
Sponsors
Centre Hospitalier Universitaire D'Angers
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For each biotherapy studied, the maximum usable concentration considered non-irritant is defined as the maximum concentration that does not produce a skin reaction in at least 9 out of 10 patients (90% specificity) during skin testing. | — |
Secondary
| Measure | Time frame |
|---|---|
| A delayed reaction is considered if, at the intradermal injection sites, a skin reaction occurs 48 hours or one week after injection, or if a systemic reaction occurs following biotherapy administration. Patients will be contacted by phone to confirm the presence or absence of a delayed local reaction, and if necessary, a photograph taken during a consultation with the allergologist investigator or in a video consultation will confirm the reaction. | — |
Countries
France
Outcome results
None listed