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Examining the effects of intravenous oxytocin infusion on peripheral sensory afferents using microneurography technique in healthy volunteers: a triple-blind, randomized, placebo-controlled trial

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-519670-39-00
Acronym
PAINOXY
Enrollment
60
Registered
2025-04-14
Start date
2025-10-13
Completion date
Unknown
Last updated
2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy participants

Brief summary

• Single afferent neuronal response (i.e., number of spike) of afferents to test filaments (1000 and 20 mN after heat-inflammation in AHTMRs and in LTMRs, respectively (see details under 10.2.1).

Detailed description

• Psychophysics I: Psychophysical quantification of touch pleasantness, • Psychophysics I: Psychophysical quantification of inflammation, • Measuring the scores on cognitive performances (information processing speed accuracy, scores on learning and memory, and maximum scores and total scores on verbal WM) contrasting oxytocin with saline infusion

Interventions

DRUGOxytocin Grindeks 8
DRUG3 mikrogram/ml injektions-/infusionsvätska
DRUGlösning
DRUG-

Sponsors

Linkopings Universitet
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
• Single afferent neuronal response (i.e., number of spike) of afferents to test filaments (1000 and 20 mN after heat-inflammation in AHTMRs and in LTMRs, respectively (see details under 10.2.1).

Secondary

MeasureTime frame
• Psychophysics I: Psychophysical quantification of touch pleasantness, • Psychophysics I: Psychophysical quantification of inflammation, • Measuring the scores on cognitive performances (information processing speed accuracy, scores on learning and memory, and maximum scores and total scores on verbal WM) contrasting oxytocin with saline infusion

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026