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A randomized, double-masked, controlled, safety and tolerability study of VRDN-003 in participants with thyroid eye disease (TED)

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-519417-57-00
Acronym
VRDN-003-303
Enrollment
76
Registered
2025-06-05
Start date
2025-06-25
Completion date
Unknown
Last updated
2025-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid eye disease

Brief summary

The primary study endpoint will assess the rate at which safety events occur after starting treatment with VRDN-003 (Treatment Emergent Adverse Event) through Week 24.

Detailed description

Changes in eye bulging at Week 24 versus measurements before the first dose., The rate at which safety events occur after starting treatment with VRDN-003 through Week 52.

Interventions

Sponsors

Viridian Therapeutics Inc.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
The primary study endpoint will assess the rate at which safety events occur after starting treatment with VRDN-003 (Treatment Emergent Adverse Event) through Week 24.

Secondary

MeasureTime frame
Changes in eye bulging at Week 24 versus measurements before the first dose., The rate at which safety events occur after starting treatment with VRDN-003 through Week 52.

Countries

France, Germany, Poland, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026