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Thiopental Induction Dose during Electroconvulsive therapy for depression (TIDE) - a randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression

Status
Not yet recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-519407-99-00
Enrollment
210
Registered
2025-03-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder

Brief summary

Change in MADRS score after six ECT sessions with a low thiopental dose compared to a high thiopental dose for anesthesia during ECT for MDD

Detailed description

• Seizure duration in the low versus high thiopental dose group • Cognitive side effects within a week after ECT and after six months • The total number of ECT sessions in a series in the low versus high thiopental dose group • Length of hospital stay in the low versus high thiopental dose group • Awareness during anesthesia in the low versus high thiopental dose group • The risk for MDD relapse within a year after ECT in the low versus high thiopental dose group

Interventions

DRUGPentocur 1 g pulver till injektionsvätska
DRUGlösning

Sponsors

Karolinska Institutet
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Change in MADRS score after six ECT sessions with a low thiopental dose compared to a high thiopental dose for anesthesia during ECT for MDD

Secondary

MeasureTime frame
• Seizure duration in the low versus high thiopental dose group • Cognitive side effects within a week after ECT and after six months • The total number of ECT sessions in a series in the low versus high thiopental dose group • Length of hospital stay in the low versus high thiopental dose group • Awareness during anesthesia in the low versus high thiopental dose group • The risk for MDD relapse within a year after ECT in the low versus high thiopental dose group

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026