Alzheimer’s Disease
Conditions
Brief summary
Change from Baseline in Tau Positron Emission Tomography (PET) Standardized Uptake Value Ratio (SUVr), Number of Participants Who Experience One or More Adverse Events (AEs), Number of Participants Who Discontinue Study Intervention Due to an AE
Detailed description
Change from Baseline in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) Total Score, Change from Baseline in the Composite Tau PET SUVr in Braak Region III and IV, Change from Baseline in the Composite Tau PET SUVr, Change from Baseline in the Composite Tau PET SUVr in Braak Region I to VI, Change from Baseline in the Alzheimer’s Disease Assessment Scale–Cognitive Subscale13 (ADAS-Cog13) Total Score, Change from Baseline in the Alzheimer’s Disease Cooperative Study Activities of Daily Living for Mild Cognitive Impairment (ADCS-ADL-MCI) Total Score, Change from Baseline in Modified Integrated Alzheimer’s Disease Rating Scale (iADRS) Total Score
Interventions
Sponsors
Merck Sharp & Dohme LLC
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline in Tau Positron Emission Tomography (PET) Standardized Uptake Value Ratio (SUVr), Number of Participants Who Experience One or More Adverse Events (AEs), Number of Participants Who Discontinue Study Intervention Due to an AE | — |
Secondary
| Measure | Time frame |
|---|---|
| Change from Baseline in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) Total Score, Change from Baseline in the Composite Tau PET SUVr in Braak Region III and IV, Change from Baseline in the Composite Tau PET SUVr, Change from Baseline in the Composite Tau PET SUVr in Braak Region I to VI, Change from Baseline in the Alzheimer’s Disease Assessment Scale–Cognitive Subscale13 (ADAS-Cog13) Total Score, Change from Baseline in the Alzheimer’s Disease Cooperative Study Activities of Daily Living for Mild Cognitive Impairment (ADCS-ADL-MCI) Total Score, Change from Baseline in Modified Integrated Alzheimer’s Disease Rating Scale (iADRS) Total Score | — |
Countries
Belgium, Netherlands, Spain
Outcome results
None listed