Posterior Urethral Valves
Conditions
Brief summary
Time to first fUTI between baseline and 2 years. The diagnosis of fUTI is defined as fever (>38.5° Celsius) with evidence of pyuria and culture-proven infection on urinalysis, obtained by urethral catheterization or suprapubic aspiration, as well as biological signs of inflammation.
Detailed description
Median number of fUTIs at 2 years in children with at least 1 fUTI during follow-up, The proportion of children with worsening renal scans (defined as an increase in heterogeneity and number of cortical defects) between baseline and 2-years between children with and without fUTIs, The types of germs responsible for fUTIs, Baseline risk factors for fUTIs from regression models (exploratory), Exploratory sub-group analyses in children with and without urinary reflux at baseline, Adherence to antibiotic prophylaxis in the control group, Absolute risk difference of first fUTI with circumcision alone versus circumcision and antibiotic prophylaxis;and antibiotic prophylaxis alone respectively.
Interventions
DRUGBactrim 40 mg/ml + 8 mg/ml mikstur
DRUGsuspensjon
DRUGALFATIL 125 mg/5 ml poudre pour suspension buvable
DRUG50 mg par ml NOURRISSONS
Sponsors
Centre Hospitalier Universitaire De Bordeaux
Eligibility
Sex/Gender
Male
Age
0 Years to 17 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first fUTI between baseline and 2 years. The diagnosis of fUTI is defined as fever (>38.5° Celsius) with evidence of pyuria and culture-proven infection on urinalysis, obtained by urethral catheterization or suprapubic aspiration, as well as biological signs of inflammation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Median number of fUTIs at 2 years in children with at least 1 fUTI during follow-up, The proportion of children with worsening renal scans (defined as an increase in heterogeneity and number of cortical defects) between baseline and 2-years between children with and without fUTIs, The types of germs responsible for fUTIs, Baseline risk factors for fUTIs from regression models (exploratory), Exploratory sub-group analyses in children with and without urinary reflux at baseline, Adherence to antibiotic prophylaxis in the control group, Absolute risk difference of first fUTI with circumcision alone versus circumcision and antibiotic prophylaxis;and antibiotic prophylaxis alone respectively. | — |
Countries
France
Outcome results
None listed