thyroid cancers
Conditions
Brief summary
To investigate the behavior of exhausted CD8+ T in response to pembrolizumab in TCs and the relationships between T cell clusters. To this aim, “spatial-transcriptomic” sequencing will be performed in tumor tissues and will be paired to single-cell maps at peripheral level before and after pembrolizumab.
Detailed description
Cancer immunotherapy aims to induce a durable human immune response in order to destroy tumour cells (Jacobson M, 2019). Biological mechanisms behind a prolonged immune response are still unknown. We hypothesize that the persistence of tumor-specific T-cell clones after the treatment of primary cancer, might contribute to a durable immune response as well as a better patients’ outcome. Single cell/spatial-transcriptomics sequencing will be applied to the blood samples collected after surgery and
Interventions
DRUGKEYTRUDA 25 mg/mL concentrate for solution for infusion
Sponsors
Istituti Clinici Scientifici Maugeri In Forma Abbreviata Istituti Clinici Scientifici Maugeri O Anche Ics Maugeri O Maugeri S.p.A. Sb
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the behavior of exhausted CD8+ T in response to pembrolizumab in TCs and the relationships between T cell clusters. To this aim, “spatial-transcriptomic” sequencing will be performed in tumor tissues and will be paired to single-cell maps at peripheral level before and after pembrolizumab. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cancer immunotherapy aims to induce a durable human immune response in order to destroy tumour cells (Jacobson M, 2019). Biological mechanisms behind a prolonged immune response are still unknown. We hypothesize that the persistence of tumor-specific T-cell clones after the treatment of primary cancer, might contribute to a durable immune response as well as a better patients’ outcome. Single cell/spatial-transcriptomics sequencing will be applied to the blood samples collected after surgery and | — |
Countries
Italy
Outcome results
None listed