Vitamin D insufficiency undergoing tooth extraction
Conditions
Brief summary
mean total IPR scores and subscores for the different wound healing phases between without (first extracted upper third molar) and with vitamin D3 intervention (second extracted upper third molar), mean salivary levels of IL-1β, IL-8, and MRP-8/14 and the dynamic of their alteration between without (first extracted upper third molar) and with vitamin D3 intervention (second extracted upper third molar), serum level of 25(OH)D3 changes in healthy participants after the vitamin D3 supplementation, frequency and severity of adverse events (AE)
Detailed description
to assess the salivary levels of several pro-inflammatory mediators, particularly interleukin (IL)-1b, IL-8, and myeloid-related protein (MRP)-8/14, measured before and at different time points after wisdom tooth extraction with and without previous vitamin D3 supplementation and to compare the time course of the inflammatory reaction.
Interventions
DRUGCOLECALCIFEROL
Sponsors
Medical University Of Vienna
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean total IPR scores and subscores for the different wound healing phases between without (first extracted upper third molar) and with vitamin D3 intervention (second extracted upper third molar), mean salivary levels of IL-1β, IL-8, and MRP-8/14 and the dynamic of their alteration between without (first extracted upper third molar) and with vitamin D3 intervention (second extracted upper third molar), serum level of 25(OH)D3 changes in healthy participants after the vitamin D3 supplementation, frequency and severity of adverse events (AE) | — |
Secondary
| Measure | Time frame |
|---|---|
| to assess the salivary levels of several pro-inflammatory mediators, particularly interleukin (IL)-1b, IL-8, and myeloid-related protein (MRP)-8/14, measured before and at different time points after wisdom tooth extraction with and without previous vitamin D3 supplementation and to compare the time course of the inflammatory reaction. | — |
Countries
Austria
Outcome results
None listed