Major patients intoxicated by functional toxicant(s), hospitalized in intensive care and intubated.
Conditions
Brief summary
Percentage change in the plasma concentration of the toxic substance(s) (ingested parent molecules) at 24 hours compared with its/their value(s) at randomisation.
Detailed description
Percentage change in plasma concentration of toxicant(s) (ingested parent molecules) at H48, H72 and H96 compared with the value at randomisation, Area under the concentration curve up to the 96th hour expressed as a percentage of the concentration at randomisation, Number of days alive without mechanical ventilation for 28 days post-randomisation, Number of days alive without resuscitation for 28 days post-randomisation, Number of episodes of vomiting, Number of ventilator-associated pneumonias, Number of episodes of upper abdominal pain and diarrhoea;, Presence of hypersensitivity reactions such as anaphylactic shock, angioedema, urticaria, rash and pruritus.
Interventions
Sponsors
Assistance Publique Hopitaux De Paris
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in the plasma concentration of the toxic substance(s) (ingested parent molecules) at 24 hours compared with its/their value(s) at randomisation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage change in plasma concentration of toxicant(s) (ingested parent molecules) at H48, H72 and H96 compared with the value at randomisation, Area under the concentration curve up to the 96th hour expressed as a percentage of the concentration at randomisation, Number of days alive without mechanical ventilation for 28 days post-randomisation, Number of days alive without resuscitation for 28 days post-randomisation, Number of episodes of vomiting, Number of ventilator-associated pneumonias, Number of episodes of upper abdominal pain and diarrhoea;, Presence of hypersensitivity reactions such as anaphylactic shock, angioedema, urticaria, rash and pruritus. | — |
Countries
France
Outcome results
None listed