Transthyretin cardiac amyloidosis
Conditions
Brief summary
Change from baseline at each point in CMR imaging parameters, including: ventricular volumes, mass, ejection fraction; native T1 and T2 mapping; ECV; LookLocker at 2, 5 and 10 minutes; LGE, Strain analysis and 4D flow
Detailed description
Frequency of heart failure related hospitalization and all-cause mortality, Change from baseline at each point in the Kansas City Cardiomyopathy, Questionnaire overall score, Change from baseline at each point in 6MWT distance, Change from baseline at each point in NT-proBNP concentration, Change from baseline at each point in NYHA classification, Change from baseline at each point in echocardiographic parameters
Interventions
Sponsors
Unidade Local De Saude De Tras-Os-Montes E Alto Douro E.P.E.
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline at each point in CMR imaging parameters, including: ventricular volumes, mass, ejection fraction; native T1 and T2 mapping; ECV; LookLocker at 2, 5 and 10 minutes; LGE, Strain analysis and 4D flow | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of heart failure related hospitalization and all-cause mortality, Change from baseline at each point in the Kansas City Cardiomyopathy, Questionnaire overall score, Change from baseline at each point in 6MWT distance, Change from baseline at each point in NT-proBNP concentration, Change from baseline at each point in NYHA classification, Change from baseline at each point in echocardiographic parameters | — |
Countries
Portugal
Outcome results
None listed