The optimal timing of vaccination in pregnancy: a multi-dimensional mechanistic approach to measure immune responses in pregnant women (MATIMMUNE)

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-518692-56-00

Enrollment

Registered

2024-10-24

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnant

Brief summary

Measurement of antibody levels and functional antibody characteristics in maternal blood with Tdap vaccination at different timings in pregnancy (measurement at baseline, after Tdap vaccination, at delivery and 6 months postpartum).

Detailed description

Measurement of cytokine levels and T-cell subsets in maternal blood after Tdap vaccination at different timings in pregnancy (measurement at baseline, after Tdap vaccination, at delivery and 6 months postpartum)., Measurement of antibody levels in cord blood at delivery after Tdap vaccination at different timings in pregnancy to calculate the transport of antibodies across the placenta., Measurement of antibody levels, subclass antibody levels, antibody glycosylation and antibody functionality in breastmilk 6 months postpartum after Tdap vaccination at different timings in pregnancy.

Interventions

DRUGTriaxis

DRUGsuspensie voor injectie in een voorgevulde spuit. Difterie

DRUGtetanus

DRUGkinkhoest (acellulaire component) vaccin (geadsorbeerd

DRUGgereduceerde antigen(en)inhoud)

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Measurement of antibody levels and functional antibody characteristics in maternal blood with Tdap vaccination at different timings in pregnancy (measurement at baseline, after Tdap vaccination, at delivery and 6 months postpartum).	—

Secondary

Measure	Time frame
Measurement of cytokine levels and T-cell subsets in maternal blood after Tdap vaccination at different timings in pregnancy (measurement at baseline, after Tdap vaccination, at delivery and 6 months postpartum)., Measurement of antibody levels in cord blood at delivery after Tdap vaccination at different timings in pregnancy to calculate the transport of antibodies across the placenta., Measurement of antibody levels, subclass antibody levels, antibody glycosylation and antibody functionality in breastmilk 6 months postpartum after Tdap vaccination at different timings in pregnancy.	—

Measure

Time frame

—

Countries

Belgium

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026