ulcerative colitis
Conditions
Brief summary
Platelet activation status will be assessed ex vivo in platelet-rich plasma (PRP) samples from UC patients (active and quiescent) and healthy controls incubated in the absence or presence of drug (tofacitinib or anti-TNFα). Regarding the in vivo study, platelet activation will be analyzed in samples from patients with active UC before and after initiating treatment with tofacitinib or anti-TNFα. It will be mesured by rate of platelet agregation
Detailed description
Endoscopic activity will be evaluated by the Mayo endoscopic sub-score; endoscopic activity will be considered as ≥ 2., Endoscopic response will be defined as a decrease of ≥ 1 point in the Mayo endoscopic sub-score 3 months after starting treatment., Endoscopic remission will be defined as an endoscopic subscore ≤1, 3 months after starting treatment.
Interventions
DRUGGOLIMUMAB
DRUGTOFACITINIB
DRUGINFLIXIMAB
DRUGADALIMUMAB
Sponsors
Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet activation status will be assessed ex vivo in platelet-rich plasma (PRP) samples from UC patients (active and quiescent) and healthy controls incubated in the absence or presence of drug (tofacitinib or anti-TNFα). Regarding the in vivo study, platelet activation will be analyzed in samples from patients with active UC before and after initiating treatment with tofacitinib or anti-TNFα. It will be mesured by rate of platelet agregation | — |
Secondary
| Measure | Time frame |
|---|---|
| Endoscopic activity will be evaluated by the Mayo endoscopic sub-score; endoscopic activity will be considered as ≥ 2., Endoscopic response will be defined as a decrease of ≥ 1 point in the Mayo endoscopic sub-score 3 months after starting treatment., Endoscopic remission will be defined as an endoscopic subscore ≤1, 3 months after starting treatment. | — |
Countries
Spain
Outcome results
None listed