Disorder of Consciousness, severe brain injury
Conditions
Brief summary
New signs of consciousness (e.g., response to command) measured by the SECONDs., Brain complexity measured by LZC and/or PCI in the ketamine session at the highest dose, compared to placebo and the baseline.
Detailed description
The “additional index” (from 0 to 100) of the SECONDs, Baseline fMRI activity in the fronto-parietal network and the thalamo-cortical loop, Baseline metabolic PET level in the fronto-parietal network and the thalamo-cortical loop, EEG alpha connectivity measured via alpha centrality, Spasticity measured via the Modified Ashworth Score, Spasticity measured via EMG recording (H/M ratio), Range of Motion
Interventions
DRUGKetalar 10mg/ml Solution for Injection/Infusion
Sponsors
Universite De Liege, Centre Hospitalier Universitaire De Liege
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| New signs of consciousness (e.g., response to command) measured by the SECONDs., Brain complexity measured by LZC and/or PCI in the ketamine session at the highest dose, compared to placebo and the baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| The “additional index” (from 0 to 100) of the SECONDs, Baseline fMRI activity in the fronto-parietal network and the thalamo-cortical loop, Baseline metabolic PET level in the fronto-parietal network and the thalamo-cortical loop, EEG alpha connectivity measured via alpha centrality, Spasticity measured via the Modified Ashworth Score, Spasticity measured via EMG recording (H/M ratio), Range of Motion | — |
Countries
Belgium
Outcome results
None listed