Cerebral neuroinflammation during major depressive episode: multicentric comparative study (InflaDep)

Conditions

Depressive disorder

Brief summary

TSPO density assessed by the cerebral distribution volume of the tracer [18F]DPA-714 in the experimental group versus the control group.

Detailed description

the density of the TSPO evaluated by the cerebral distribution volume of the tracer [18F]DPA-714 in the 3 groups (experimental, control and pathological control)., psychometric scales making it possible to assess the clinical state of subjects: o Depression scale (MADRS) o Anhedonia Scale (SHAPS) o Psychomotor slowing scale (Widlocher scale) o Suicide Risk Rating Scale (CSSRS) o BAS Anxiety Rating Scale (Brief Scale for Anxiety), imagery markers o by structural MRI (i.e. the cortical thickness allowing the quantification of cortical atrophy) o diffusion (i.e. the average diffusivity allowing microstructural integrity to be measured) o T2* relaxometry (i.e. R2* to measure intracerebral iron content) o Resting functional MRI (i.e. connectivity strength of the default mode network), concentrations of biological markers of peripheral inflammation (TNF alpha and IL6), Proteomics: identification of plasma proteins and relative quantification of their abundances

Related papers

No related papers found yet.

Papers published before 2007-09-01 may not appear yet. Historical indexing is in progress.

Interventions

DRUG18F-DPA-714

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
TSPO density assessed by the cerebral distribution volume of the tracer [18F]DPA-714 in the experimental group versus the control group.	—

Secondary

Measure	Time frame
the density of the TSPO evaluated by the cerebral distribution volume of the tracer [18F]DPA-714 in the 3 groups (experimental, control and pathological control)., psychometric scales making it possible to assess the clinical state of subjects: o Depression scale (MADRS) o Anhedonia Scale (SHAPS) o Psychomotor slowing scale (Widlocher scale) o Suicide Risk Rating Scale (CSSRS) o BAS Anxiety Rating Scale (Brief Scale for Anxiety), imagery markers o by structural MRI (i.e. the cortical thickness allowing the quantification of cortical atrophy) o diffusion (i.e. the average diffusivity allowing microstructural integrity to be measured) o T2* relaxometry (i.e. R2* to measure intracerebral iron content) o Resting functional MRI (i.e. connectivity strength of the default mode network), concentrations of biological markers of peripheral inflammation (TNF alpha and IL6), Proteomics: identification of plasma proteins and relative quantification of their abundances	—

Measure

Time frame

the density of the TSPO evaluated by the cerebral distribution volume of the tracer [18F]DPA-714 in the 3 groups (experimental, control and pathological control)., psychometric scales making it possible to assess the clinical state of subjects: o Depression scale (MADRS) o Anhedonia Scale (SHAPS) o Psychomotor slowing scale (Widlocher scale) o Suicide Risk Rating Scale (CSSRS) o BAS Anxiety Rating Scale (Brief Scale for Anxiety), imagery markers o by structural MRI (i.e. the cortical thickness allowing the quantification of cortical atrophy) o diffusion (i.e. the average diffusivity allowing microstructural integrity to be measured) o T2* relaxometry (i.e. R2* to measure intracerebral iron content) o Resting functional MRI (i.e. connectivity strength of the default mode network), concentrations of biological markers of peripheral inflammation (TNF alpha and IL6), Proteomics: identification of plasma proteins and relative quantification of their abundances

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Countries

France

Outcome results

None listed