but also inpatients undergoing surgery who are ASA 1 and 2., Health status ASA1 or ASA2 as categorised by a medical doctor at the hospital based on medical history and physical examination. The American Society of Anesthesiologists physical status (ASA1: "Healthy, non-smoking, no or minimal alcohol use" and ASA 2: "Mild diseases only without substantive functional limitations). Being eligible for day surgery means participants are overtly healthy as determined by clinical staff
Conditions
Brief summary
The primary endpoints will be the mean ratings for each drug as follows (rated by the participants on the operating table using a verbal numeric rating scale (NRS 0-10))., Self-report items: - Numeric rating scales (0-10) on affective states ( pre-drug rating): Good, pain,relaxed,anxious, After IV drug administration, the patients is asked to indicate when they first feel a drug effect, and the time (seconds post-administration) is recorded along with the patient's description of this effect, after a standardized waiting time (2 min)the study personnel ask further questions about the patients' affective state. In the case that no effect has been indicated within the first two minutes, patients are asked if they feel an effect and if so, to describe it. The patient is then asked to report on an NRS 0-10, again how "good", "anxious", "pain", and "relaxed" they feel on a numerical rating scale NRS 0-10. We also measure acute drug effects such as "high", "liking the effect", "disli
Detailed description
Mean differences on the objective measures pre- and post opioid administration between the different drug groups: -HRV (heartrate variability), Multiple regressions will be fit to the subjective outcome measures (post-opioid) to investigate variability explained by measures at preopioid. Specifically, the predictor value of measures identified as risk factors for problematic opioid use in previous studies (e.g. prior opioid use, SUD and depression) will be assessed on the subjective items below: • Good • Pain • anxious • Relaxed • Drug high • Euphoric • Drug liking
Interventions
Sponsors
Vestre Viken HF
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints will be the mean ratings for each drug as follows (rated by the participants on the operating table using a verbal numeric rating scale (NRS 0-10))., Self-report items: - Numeric rating scales (0-10) on affective states ( pre-drug rating): Good, pain,relaxed,anxious, After IV drug administration, the patients is asked to indicate when they first feel a drug effect, and the time (seconds post-administration) is recorded along with the patient's description of this effect, after a standardized waiting time (2 min)the study personnel ask further questions about the patients' affective state. In the case that no effect has been indicated within the first two minutes, patients are asked if they feel an effect and if so, to describe it. The patient is then asked to report on an NRS 0-10, again how "good", "anxious", "pain", and "relaxed" they feel on a numerical rating scale NRS 0-10. We also measure acute drug effects such as "high", "liking the effect", "dis | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean differences on the objective measures pre- and post opioid administration between the different drug groups: -HRV (heartrate variability), Multiple regressions will be fit to the subjective outcome measures (post-opioid) to investigate variability explained by measures at preopioid. Specifically, the predictor value of measures identified as risk factors for problematic opioid use in previous studies (e.g. prior opioid use, SUD and depression) will be assessed on the subjective items below: • Good • Pain • anxious • Relaxed • Drug high • Euphoric • Drug liking | — |
Countries
Norway
Outcome results
None listed