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A Multinational, Long-Term, Open-Label Extension Study of Subjects Who Have Participated in Avalyn Pharma Studies of Inhaled Antifibrotic Agents (AP-LTE-008 [Sail])

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-518289-28-00
Acronym
AP-LTE-008
Enrollment
121
Registered
2025-06-03
Start date
2025-07-04
Completion date
Unknown
Last updated
2026-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Progressive pulmonary fibrosis [PPF] Idiopathic pulmonary fibrosis [IPF]

Brief summary

Incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs), Incidence of adverse events of special interest (AESIs), Incidence of treatment-emergent all-cause deaths, Incidence of treatment-emergent respiratory deaths, Incidence of exacerbation of pulmonary fibrosis, Changes from baseline in clinical laboratory tests and vital signs

Detailed description

Change from baseline in forced vital capacity (FVC) (mL) at intervals of 6 months, Annual rate of decline in FVC (mL)

Interventions

Sponsors

Avalyn Pharma Inc.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs), Incidence of adverse events of special interest (AESIs), Incidence of treatment-emergent all-cause deaths, Incidence of treatment-emergent respiratory deaths, Incidence of exacerbation of pulmonary fibrosis, Changes from baseline in clinical laboratory tests and vital signs

Secondary

MeasureTime frame
Change from baseline in forced vital capacity (FVC) (mL) at intervals of 6 months, Annual rate of decline in FVC (mL)

Countries

Czechia, France, Germany, Italy, Netherlands, Poland, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026