Comparison of Landiolol versus standard of care for prevention of mortality in patients hospitalized for a septic shock with hypercontractlity: an open label prospective randomized study

Conditions

patients hospitalized for a septic shock with hypercontractlity

Brief summary

mortality at day 28

Detailed description

- Number of patients that achieved a reduction of heart rate equal or higher to 20% of the initial HR with landiolol, - Number of days receiving catecholamines, - Number of days receiving mechanical ventilation, - Length of stay in ICU and hospital, - SOFA score at inclusion and day 1, 2, 3, 7, 14 and 28 following the inclusion, - Number of patients developing atrial fibrillation of flutter during the first three days, - Hospital mortality, - Number of episodes of bradycardia (<50 bpm) or LVEF < 45% or MAP <65mmHg requiring an increase of Norepinephrine > 40% during the entire period of treatment with the landiolol, - Unexpected cardiac arrest

Related papers

No related papers found yet.

Papers published before 2008-02-04 may not appear yet. Historical indexing is in progress.

Interventions

DRUGCHLORURE DE SODIUM 0

DRUG9 % AGUETTANT

DRUGsolution pour perfusion

DRUGRapibloc 300 mg powder for solution for infusion.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
mortality at day 28	—

Secondary

Measure	Time frame
- Number of patients that achieved a reduction of heart rate equal or higher to 20% of the initial HR with landiolol, - Number of days receiving catecholamines, - Number of days receiving mechanical ventilation, - Length of stay in ICU and hospital, - SOFA score at inclusion and day 1, 2, 3, 7, 14 and 28 following the inclusion, - Number of patients developing atrial fibrillation of flutter during the first three days, - Hospital mortality, - Number of episodes of bradycardia (<50 bpm) or LVEF < 45% or MAP <65mmHg requiring an increase of Norepinephrine > 40% during the entire period of treatment with the landiolol, - Unexpected cardiac arrest	—

Measure

Time frame

- Number of patients that achieved a reduction of heart rate equal or higher to 20% of the initial HR with landiolol, - Number of days receiving catecholamines, - Number of days receiving mechanical ventilation, - Length of stay in ICU and hospital, - SOFA score at inclusion and day 1, 2, 3, 7, 14 and 28 following the inclusion, - Number of patients developing atrial fibrillation of flutter during the first three days, - Hospital mortality, - Number of episodes of bradycardia (<50 bpm) or LVEF < 45% or MAP <65mmHg requiring an increase of Norepinephrine > 40% during the entire period of treatment with the landiolol, - Unexpected cardiac arrest

—

Countries

France

Outcome results

None listed