Reward-specific changes of cerebral dopamine synthesis in healthy volunteers and depressed patients

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-518226-32-00

Acronym

18F-FDOPA-BUP-ESC

Enrollment

120

Registered

2025-01-15

Start date

2023-01-05

Completion date

Unknown

Last updated

2025-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depression

Brief summary

Reward-specific changes of dopamin-synthesis

Detailed description

To analyze the relationship between reward-specific dopamine synthesis and fMRI activation across healthy volunteers and patients with MDD, To identify remission rates in MDD patients being treated with either escitalopram OR bupropion in a longitudinal design, Test-retest reliability for the quantification of dopamine synthesis rates in healthy volunteers

Interventions

DRUGCipralex® 10 mg – Filmtabletten

DRUGWellbutrin XR 150 mg-Retardtabletten

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Reward-specific changes of dopamin-synthesis	—

Secondary

Measure	Time frame
To analyze the relationship between reward-specific dopamine synthesis and fMRI activation across healthy volunteers and patients with MDD, To identify remission rates in MDD patients being treated with either escitalopram OR bupropion in a longitudinal design, Test-retest reliability for the quantification of dopamine synthesis rates in healthy volunteers	—

Countries

Austria

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026