Upper-limb Active Function and Botulinum Toxin A

Conditions

Stroke

Brief summary

Measurement of the spastic cocontraction index (ICCS) during active elbow extension movement, obtained from the EMG signal of the elbow extensor and flexor muscles on the paretic side, between T1 and T2 (before versus 4 weeks after TBA injection)

Detailed description

Spasticity of the elbow flexors according to Tardieu, Limitation of the active movement angle (LAMA) of elbow extension, Fugl-Meyer score (motor selectivity), Functional abilities with the Wolf Motor Function Test (WMFT) score, EEG quantification of bilateral cortical activity during movement (real or imagined) to calculate the following indices: o desynchronization index (ERD) identifying hyperactivity in the ipsilesional cortex; o synchronization index quotient (ERS) to assess interhemispheric inhibition (inhibition laterality coefficient) o amount of interhemispheric coherence, Corticospinal excitability (curve of variation of MEP amplitude as a function of stimulation intensity) assessed by TMS, Anatomical lesions of the motor pathways (motor cortex and descending motor pathways) obtained from anatomical (T1) and diffusion-weighted MRI

Related papers

No related papers found yet.

Interventions

DRUGDysport 500 U

DRUGpoudre pour solution injectable

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Measurement of the spastic cocontraction index (ICCS) during active elbow extension movement, obtained from the EMG signal of the elbow extensor and flexor muscles on the paretic side, between T1 and T2 (before versus 4 weeks after TBA injection)	—

Secondary

Measure	Time frame
Spasticity of the elbow flexors according to Tardieu, Limitation of the active movement angle (LAMA) of elbow extension, Fugl-Meyer score (motor selectivity), Functional abilities with the Wolf Motor Function Test (WMFT) score, EEG quantification of bilateral cortical activity during movement (real or imagined) to calculate the following indices: o desynchronization index (ERD) identifying hyperactivity in the ipsilesional cortex; o synchronization index quotient (ERS) to assess interhemispheric inhibition (inhibition laterality coefficient) o amount of interhemispheric coherence, Corticospinal excitability (curve of variation of MEP amplitude as a function of stimulation intensity) assessed by TMS, Anatomical lesions of the motor pathways (motor cortex and descending motor pathways) obtained from anatomical (T1) and diffusion-weighted MRI	—

Measure

Time frame

Spasticity of the elbow flexors according to Tardieu, Limitation of the active movement angle (LAMA) of elbow extension, Fugl-Meyer score (motor selectivity), Functional abilities with the Wolf Motor Function Test (WMFT) score, EEG quantification of bilateral cortical activity during movement (real or imagined) to calculate the following indices: o desynchronization index (ERD) identifying hyperactivity in the ipsilesional cortex; o synchronization index quotient (ERS) to assess interhemispheric inhibition (inhibition laterality coefficient) o amount of interhemispheric coherence, Corticospinal excitability (curve of variation of MEP amplitude as a function of stimulation intensity) assessed by TMS, Anatomical lesions of the motor pathways (motor cortex and descending motor pathways) obtained from anatomical (T1) and diffusion-weighted MRI

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Countries

France

Outcome results

None listed