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A randomized, placebo controlled, double blind, double dummy, multicenter trial comparing electronic cigarettes with nicotine to varenicline and to electronic cigarettes without nicotine. ECSMOKE

Status
Not yet recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-518135-10-00
Acronym
P150952J
Enrollment
650
Registered
2024-10-31
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smokers smoking at least 10 cigarettes/day in the past year

Brief summary

Continuous smoking abstinence rate during the last 4 weeks of a treatment period of 3 months.

Detailed description

The assessment criterion of the safety will be the comparison of serious adverse events and non-serious adverse events, Point prevalence abstinence: self-report of 7-day smoking abstinence at each visit associated with expired air CO ≤ 8 ppm., Time to relapse to smoking after the predefined target quit day, Change in cigarettes/day consumption, Change in craving for tobacco, Change in withdrawal symptoms

Interventions

DRUGCHAMPIX 0.5 mg film-coated tablets
DRUGPlacebo CHAMPIX ® 0.5mg Comprimé pelliculé

Sponsors

Assistance Publique Hopitaux De Paris
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Continuous smoking abstinence rate during the last 4 weeks of a treatment period of 3 months.

Secondary

MeasureTime frame
The assessment criterion of the safety will be the comparison of serious adverse events and non-serious adverse events, Point prevalence abstinence: self-report of 7-day smoking abstinence at each visit associated with expired air CO ≤ 8 ppm., Time to relapse to smoking after the predefined target quit day, Change in cigarettes/day consumption, Change in craving for tobacco, Change in withdrawal symptoms

Countries

France

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026