Atherosclerosis, Cancer
Conditions
Brief summary
Change in maximum target-to-background ratio (TBRmax) in coronary arteries, which quantifies 68Gallium-DOTATATE uptake, between baseline and 12-week follow-up on PET-scan.
Detailed description
TBRmax in carotid arteries, TBRmax in aorta, Mean standardized uptake value (SUVmean) in spleen, SUVmean in bone marrow, Coronary artery calcium score, Major adverse cardiovascular events (i.e. myocardial infarction, ischemic stroke, ischemia-driven coronary revascularisation, death), All-cause mortality, Immune related adverse events, Biomarkers (e.g. blood inflammatory markers, PBMCs, plasma cytokines, metabolomics, and microbiome composition)
Interventions
DRUG-
DRUGCOLCHICINE
Sponsors
Amsterdam UMC Stichting
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in maximum target-to-background ratio (TBRmax) in coronary arteries, which quantifies 68Gallium-DOTATATE uptake, between baseline and 12-week follow-up on PET-scan. | — |
Secondary
| Measure | Time frame |
|---|---|
| TBRmax in carotid arteries, TBRmax in aorta, Mean standardized uptake value (SUVmean) in spleen, SUVmean in bone marrow, Coronary artery calcium score, Major adverse cardiovascular events (i.e. myocardial infarction, ischemic stroke, ischemia-driven coronary revascularisation, death), All-cause mortality, Immune related adverse events, Biomarkers (e.g. blood inflammatory markers, PBMCs, plasma cytokines, metabolomics, and microbiome composition) | — |
Countries
Netherlands
Outcome results
None listed