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MOOD - MethOxyflurane analgesia in vasoOcclusive crises of sickle cell Disease

Status
Withdrawn
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-518043-38-00
Enrollment
198
Registered
2026-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sickle cell disease

Brief summary

The mean pain intensity measured by VAS (Visual Analogic Scale) every 10 minutes during the first hour after admission in the emergency department

Detailed description

Patient's satisfaction measured at the 60th minute by Likert scale ranging from 1 to 10., Global ED nurse's satisfaction measured within the first 8h by Likert scale ranging from 1 to 10., Total amount (in milligram) of intravenous morphine and analgesics (Nefopam, Paracetamol, and Tramadol) administered until emergency discharge, Duration of stay (in days) from arrival to emergency department to the end of hospitalization., Calculation of the cost of Penthrox® (number of bottles used), Calculation of the cost of oral administration of opioid analgesics (number of pills used), such as Oral Oxycodone Hydrochloride (OxynormORO®) or Morphine Sulfate (Actiskenan® ), Incidence of renal and liver events based on the difference of kidney and liver function between the time of emergency admission and the third to seventh day of hospitalization (if several values are available, the worse value is retained), Incidence of acute chest syndrome during hospitalization, Incidence of neurologic events such as ischemic stroke

Interventions

Sponsors

Assistance Publique Hopitaux De Paris
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
The mean pain intensity measured by VAS (Visual Analogic Scale) every 10 minutes during the first hour after admission in the emergency department

Secondary

MeasureTime frame
Patient's satisfaction measured at the 60th minute by Likert scale ranging from 1 to 10., Global ED nurse's satisfaction measured within the first 8h by Likert scale ranging from 1 to 10., Total amount (in milligram) of intravenous morphine and analgesics (Nefopam, Paracetamol, and Tramadol) administered until emergency discharge, Duration of stay (in days) from arrival to emergency department to the end of hospitalization., Calculation of the cost of Penthrox® (number of bottles used), Calculation of the cost of oral administration of opioid analgesics (number of pills used), such as Oral Oxycodone Hydrochloride (OxynormORO®) or Morphine Sulfate (Actiskenan® ), Incidence of renal and liver events based on the difference of kidney and liver function between the time of emergency admission and the third to seventh day of hospitalization (if several values are available, the worse value is retained), Incidence of acute chest syndrome during hospitalization, Incidence of neurologic event

Outcome results

None listed

Source: EU CTIS · Data processed: May 30, 2026