A blinded randomized study of ephedrine 0.15 mg/kg for reducing onset time of rocuronium 0.6 mg/kg in elderly patients (≥ 80 years)

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-517933-42-00

Enrollment

100

Registered

2024-11-13

Start date

2025-01-13

Completion date

2025-10-05

Last updated

2024-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective surgery

Brief summary

Time to TOF 0 (from end of administration of rocuronium until TOF 0)

Detailed description

Intubating conditions assessed by IDS, Intubating conditions assessed by Fuchs-Buder scale, Occurrence of new cardiac arrythmia during induction of anaesthesia (<15 minutes after administration of ephedrine or saline), Change in mean arterial blood pressure from before induction to immediately after intubation, Time to TOF 0.9

Interventions

DRUGEphedrine "Sintetica"

DRUGinjektionsvæske

DRUGopløsning 50 mg/ml

DRUGSALINE

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Time to TOF 0 (from end of administration of rocuronium until TOF 0)	—

Secondary

Measure	Time frame
Intubating conditions assessed by IDS, Intubating conditions assessed by Fuchs-Buder scale, Occurrence of new cardiac arrythmia during induction of anaesthesia (<15 minutes after administration of ephedrine or saline), Change in mean arterial blood pressure from before induction to immediately after intubation, Time to TOF 0.9	—

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026