Early start corticosteroids versus standard care (RASBs followed by corticosteroids) for proteinuria in Immunoglobulin A Nephropathy (IgAN) patients with active renal lesions identified by kidney biopsy and RASBs combined with corticosteroids versus sodium-glucose cotransporter2 inhibitor combined with RASBs for proteinuria and renal function in IgAN patients with chronic renal lesions identified by kidney biopsy. A PROJECT FOR TWO MULTICENTRE, PROSPECTIVE OPEN LABEL RANDOMIZED CLINICAL STUDIES TO EVALUATE THE EFFECT OF TARGETED THERAPY BASED ON KIDNEY BIOPSY FINDINGS IN IgAN PATIENTS (CLIgAN)

Idiopathic IgA nephropathy (IgAN)

Between-arms difference in proteinuria reduction within 4 months and in nonresponders within 8 months in ACIgAN study., Between-arms difference in proteinuria reduction within 10 months in CHRONIgAN study.

eGFR slope calculated as mean of individual slope obtained from individual linear regression of eGFR overtime (3 years);, eGFR decline > 40 % from the baseline value;, composite end point: GFR decline > 40%, ESKD (defined as long-term GFR <= 15 ml/min/1.73m2 for more than three months or need for maintenance dialysis or kidney transplantation) or death due to kidney disease;, absolute difference between last GFR value and baseline GFR;, stable renal function defined as a decline in GFR <= 5 ml/min/1.73m2 at the end of three years follow- up, mean annual change in the slope of the reciprocal of serum creatinine concentration;, time-averaged proteinuria (TA-P) calculated as the weighted mean of all postrandomisation measurement, with weights representing the time elapsed since the previous measurement;, proteinuria slope, calculated as a mean of individual slope, obtained from individual linear regression of daily proteinuria overtime (3 years);, complete remission of proteinuria defined as achievement of urinary protein level <= 0.2 g/day or a urinary protein-to-creatinine ratio <= 0.2 g/g;, partial remission of proteinuria defined as achievement of a urinary protein reduction >= 50% or greater compared with the baseline value.

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