Healthy volunteers
Conditions
Brief summary
Psychobiological readouts related to stress and fear tasks, including salivary cortisol levels, subjective visual analogue scale (VAS) stress reports, skin conductance levels, and expectancy of dangerous stimulus (expectancy ratings)
Detailed description
Gut microbiota profile, heart rate variability, SCFA levels, inflammatory marker profile (cytokine panel and C-reactive protein levels), fMRI BOLD responses to stress, and brain metabolite concentration
Interventions
DRUGTARGAXAN 550 mg Filmtabletten
DRUGThe placebo tablets are white to off-white tablets with a mean weight of 488 mg
DRUGminimum hardness of 50 N and a mean thickness of about 5.7 mm.
The following formula will be used in the manufacturing of the placebo tablets:
Ingredient Amount/tablet
Lactose monohydrate 320 mg
Carmellose Sodium 10 mg
Corn starch 70 mg
Cellulose microcrystalline 55 mg
Sillicium dioxide anhydrous 20 mg
Magnesium stearate 13 mg
Total tablet weight 488 mg
Sponsors
UZ Leuven
Eligibility
Sex/Gender
Male
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychobiological readouts related to stress and fear tasks, including salivary cortisol levels, subjective visual analogue scale (VAS) stress reports, skin conductance levels, and expectancy of dangerous stimulus (expectancy ratings) | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota profile, heart rate variability, SCFA levels, inflammatory marker profile (cytokine panel and C-reactive protein levels), fMRI BOLD responses to stress, and brain metabolite concentration | — |
Countries
Belgium
Outcome results
None listed