Patients with drug-resistant epilepsy who are candidates for surgery requiring SEEG.
Conditions
Brief summary
Percentage of subjects in whom the epileptogenic volume defined by SEEG performed according to the electrode implantation plan determined with multimodal PET-MRI imaging (VE2) will have been correctly modified compared with the electrode implantation plan determined without multimodal imaging data (VE1).
Detailed description
Collection and analysis of adverse events and their causal relationship in relation to the entire procedure evaluated., Number of subjects who benefited from the entire procedure in accordance with the protocol., Number of seizures in patients 1 year after surgery (ILAE classification)., Study of imaging results in subgroups of patients according to the type epilepsy (temporal or extra-temporal localization, etiology of epilepsy epilepsy, seizure frequency)., Imaging data in patients not cured by surgery., Imaging data in patients rejected after SEEG., Topography of PET imaging data 18F-DPA-714 PET vs. MRI data., Relationship between epileptic focus and remote brain function.
Interventions
DRUG18F-DPA-714
Sponsors
Commissariat a l'Energie Atomique et aux Energies Alternatives
Eligibility
Sex/Gender
All
Age
0 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of subjects in whom the epileptogenic volume defined by SEEG performed according to the electrode implantation plan determined with multimodal PET-MRI imaging (VE2) will have been correctly modified compared with the electrode implantation plan determined without multimodal imaging data (VE1). | — |
Secondary
| Measure | Time frame |
|---|---|
| Collection and analysis of adverse events and their causal relationship in relation to the entire procedure evaluated., Number of subjects who benefited from the entire procedure in accordance with the protocol., Number of seizures in patients 1 year after surgery (ILAE classification)., Study of imaging results in subgroups of patients according to the type epilepsy (temporal or extra-temporal localization, etiology of epilepsy epilepsy, seizure frequency)., Imaging data in patients not cured by surgery., Imaging data in patients rejected after SEEG., Topography of PET imaging data 18F-DPA-714 PET vs. MRI data., Relationship between epileptic focus and remote brain function. | — |
Countries
France
Outcome results
None listed