Colon cancer
Conditions
Brief summary
• Differences in measures of lymphocytic subpopulations (FLOW) between intervention and placebo group, seen as a higher number of CD3, 4, 8 and HLA-positive cells in the intervention group, on the day of and the day after surgery. • Differences in tumor-infiltrating lymphocytes in the resected specimen at the tumor center and invasive margin between the intervention and placebo group. This will be analysed via immunohistochemistry with staining for CD3+, CD4+ and CD8+ T-cells.
Detailed description
A few of them: 1)Differences in measures of Quality of recovery (QoR-15) between intervention and placebo group, seen as a higher mean QoR in intervention group on the third and 12-16 post-operative day. 2) Differences in phenotype and clonality of tumor-infiltrating and circulating T cells between placebo and intervention group, analyzed via combined single-cell transcriptome and TCR sequencing. 3) Differences in tumor microenvironment in the resected specimen.
Interventions
Sponsors
Region Sjaelland
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Differences in measures of lymphocytic subpopulations (FLOW) between intervention and placebo group, seen as a higher number of CD3, 4, 8 and HLA-positive cells in the intervention group, on the day of and the day after surgery. • Differences in tumor-infiltrating lymphocytes in the resected specimen at the tumor center and invasive margin between the intervention and placebo group. This will be analysed via immunohistochemistry with staining for CD3+, CD4+ and CD8+ T-cells. | — |
Secondary
| Measure | Time frame |
|---|---|
| A few of them: 1)Differences in measures of Quality of recovery (QoR-15) between intervention and placebo group, seen as a higher mean QoR in intervention group on the third and 12-16 post-operative day. 2) Differences in phenotype and clonality of tumor-infiltrating and circulating T cells between placebo and intervention group, analyzed via combined single-cell transcriptome and TCR sequencing. 3) Differences in tumor microenvironment in the resected specimen. | — |
Countries
Denmark
Outcome results
None listed