Nitrous Oxide in Resistant Depression in Elderly Subjects: A Randomized, Double-blind, Comparator Trial

Conditions

Resistant Depression in the Elderly Subject

Brief summary

MADRS Depression Severity Scale collected collected at baseline, 2 hours, 24 hours, Week 1 and Week 2 in MEOPA vs comparator group

Detailed description

Brain Pulsatility Indices as measured by IPT Ultrasound Imaging, Brain volume and white matter lesion indices measured by MRI, indicators of brain atrophy and lesion load; Brain perfusion indices measured by MRI-ASL; Pulsatilité́ and Brain Connectivity indices as measured by MRI in BOLD signal, A series of scales complementary to the MADRS for the evolution of depressive symptoms (Hamilton 17-items, CGI - Clinical Global Impression, QIDS-SR - Quick Inventory of Depressive Symptomatology Self Report), A series of scales for the evaluation of possible adverse effects (SSI - Scale for Suicidal Ideation, YMRS - Young Mania Rating Scale, CADSS - Clinician Administered Dissociative States Scale, BPRS - Brief Psychiatric Rating Scale)

Related papers

No related papers found yet.

Interventions

DRUGMedical Air

DRUGKALINOX 50%/50%

DRUGgaz médicinal comprimé

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
MADRS Depression Severity Scale collected collected at baseline, 2 hours, 24 hours, Week 1 and Week 2 in MEOPA vs comparator group	—

Secondary

Measure	Time frame
Brain Pulsatility Indices as measured by IPT Ultrasound Imaging, Brain volume and white matter lesion indices measured by MRI, indicators of brain atrophy and lesion load; Brain perfusion indices measured by MRI-ASL; Pulsatilité́ and Brain Connectivity indices as measured by MRI in BOLD signal, A series of scales complementary to the MADRS for the evolution of depressive symptoms (Hamilton 17-items, CGI - Clinical Global Impression, QIDS-SR - Quick Inventory of Depressive Symptomatology Self Report), A series of scales for the evaluation of possible adverse effects (SSI - Scale for Suicidal Ideation, YMRS - Young Mania Rating Scale, CADSS - Clinician Administered Dissociative States Scale, BPRS - Brief Psychiatric Rating Scale)	—

Measure

Time frame

Brain Pulsatility Indices as measured by IPT Ultrasound Imaging, Brain volume and white matter lesion indices measured by MRI, indicators of brain atrophy and lesion load; Brain perfusion indices measured by MRI-ASL; Pulsatilité́ and Brain Connectivity indices as measured by MRI in BOLD signal, A series of scales complementary to the MADRS for the evolution of depressive symptoms (Hamilton 17-items, CGI - Clinical Global Impression, QIDS-SR - Quick Inventory of Depressive Symptomatology Self Report), A series of scales for the evaluation of possible adverse effects (SSI - Scale for Suicidal Ideation, YMRS - Young Mania Rating Scale, CADSS - Clinician Administered Dissociative States Scale, BPRS - Brief Psychiatric Rating Scale)

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Countries

France

Outcome results

None listed