severe asthma and chronic rhinosinusitis with nasal polyps, severe asthma without chronic rhinosinusitis
Conditions
Brief summary
Changes in normalized cell index in response to barrier-damaging substances in cultured primary epithelial cells of the different disease entities using the xCELLigence system for continuous monitoring of barrier function.
Detailed description
Mucus plugging: CT scan, Cellular composition: percentage of populations and mean metal intensity (marker expression), Inflammatory mediator expression: Levels (e.g. ng/mL), Microbiome: Composition, Diversity Indices, Tight junction protein staining: mean fluorescence intensity, Association: Pearson or Spearman-rank correlation coefficient depending on data distribution
Interventions
DRUGTEZEPELUMAB
Sponsors
Medical University Of Vienna
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in normalized cell index in response to barrier-damaging substances in cultured primary epithelial cells of the different disease entities using the xCELLigence system for continuous monitoring of barrier function. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mucus plugging: CT scan, Cellular composition: percentage of populations and mean metal intensity (marker expression), Inflammatory mediator expression: Levels (e.g. ng/mL), Microbiome: Composition, Diversity Indices, Tight junction protein staining: mean fluorescence intensity, Association: Pearson or Spearman-rank correlation coefficient depending on data distribution | — |
Countries
Austria
Outcome results
None listed