Evaluation of the effect of phenofibrate on the functions of beta cells in children with new diagnosis of type 1 diabetes
Conditions
Brief summary
Assessment of pancreatic beta cell function by comparing the AUC area under the curve in the C-peptide stimulation test: Change in the mean insulin secretion measured based on the C-peptide area under the curve in the stimulation test at individual time points in the compared groups of patients
Detailed description
• Fasting c-peptide concentration and maximum c-peptide concentration in the stimulation test, • Parameters of diabetes control and glucose fluctuations (including HbA1c, mean blood glucose with standard deviation, variability index, time spent in normoglycemia), • Daily and basic insulin requirements • Inflammation markers • Safety and tolerance of the fenofibrate
Interventions
Sponsors
Medical University Of Warsaw
Eligibility
Sex/Gender
All
Age
0 Years to 17 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of pancreatic beta cell function by comparing the AUC area under the curve in the C-peptide stimulation test: Change in the mean insulin secretion measured based on the C-peptide area under the curve in the stimulation test at individual time points in the compared groups of patients | — |
Secondary
| Measure | Time frame |
|---|---|
| • Fasting c-peptide concentration and maximum c-peptide concentration in the stimulation test, • Parameters of diabetes control and glucose fluctuations (including HbA1c, mean blood glucose with standard deviation, variability index, time spent in normoglycemia), • Daily and basic insulin requirements • Inflammation markers • Safety and tolerance of the fenofibrate | — |
Countries
Poland
Outcome results
None listed