Influence of antibiotic treatment on the normal flora and the presence of resistance genes in known carriers of ESBL and VRE

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-517434-17-01

Enrollment

Registered

2024-10-25

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ESBL Carriage, VRE Carriage

Brief summary

1 a) Transition from negative to positive fecal screen for VRE/EPE directly after antibiotic challenge. 1b) Differences in the microbiota's composition and diversity compared to before antibitoic challenge.

Detailed description

2a) Time for participants who transitioned from negative to positive VRE/EPE carriage to transition back to negative. 2b) Time for the intestinal microbiota's composition and diversity to return to baseline. 2c) Differences regarding detection of resistance in with conventional methods compared to metagenomic methods, defined as discordant results.

Interventions

DRUGCIPROFLOXACIN

DRUGVANCOMYCIN

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
1 a) Transition from negative to positive fecal screen for VRE/EPE directly after antibiotic challenge. 1b) Differences in the microbiota's composition and diversity compared to before antibitoic challenge.	—

Secondary

Measure	Time frame
2a) Time for participants who transitioned from negative to positive VRE/EPE carriage to transition back to negative. 2b) Time for the intestinal microbiota's composition and diversity to return to baseline. 2c) Differences regarding detection of resistance in with conventional methods compared to metagenomic methods, defined as discordant results.	—

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026