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Preoperative Lugol’s solution in Graves’ disease and toxic nodular goiter

Status
Not yet recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-517110-15-00
Acronym
LugolProtocol001
Enrollment
182
Registered
2024-08-15
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperthyroidism

Brief summary

Pilot study: Response of TSH, fT4, fT3 and heart rate after 10 days of administration of iodine solution. Main study: Occurance of postoperative temporary hypoparathyroidism. Pilot study: Serum levels of TSH, fT4, fT3 and heart rate day 0, day 3-4, day 6-7 and day 10 after administration of iodine solution. Main study: Immediately postoperatively and 1 month post surgery

Detailed description

Pilot study: evaluation of quality of life after treatment with iodine solution. Main study: Occurance of postoperative permanent hypoparathyroidism. Occurance of postoperative temporary and permanent recurrant nerve palsy. Evaluation of quality of Life.

Interventions

DRUG-

Sponsors

Karolinska University Hospital
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Secondary

MeasureTime frame
Pilot study: evaluation of quality of life after treatment with iodine solution. Main study: Occurance of postoperative permanent hypoparathyroidism. Occurance of postoperative temporary and permanent recurrant nerve palsy. Evaluation of quality of Life.

Primary

MeasureTime frame
Pilot study: Response of TSH, fT4, fT3 and heart rate after 10 days of administration of iodine solution. Main study: Occurance of postoperative temporary hypoparathyroidism. Pilot study: Serum levels of TSH, fT4, fT3 and heart rate day 0, day 3-4, day 6-7 and day 10 after administration of iodine solution. Main study: Immediately postoperatively and 1 month post surgery

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026