Tau and Amyloid PET imaging in normal aging, early Alzheimer's disease and related syndroms.

Conditions

Alzheimer's disease

Brief summary

F18-MK6240 regional SUVr or spatial extension measure differences between patients and controls

Detailed description

Associations between F18-MK6240 regional SUVr or spatial extension measures and: Cognitive outcomes - Global cognitive measures - Verbal Episodic Memory - Visuospatial/Constructional - Language - Attention/Executive Functioning - Spatial navigational skills; - Face perception and recognition abilities; Specific semantic memory measures; - Short-term memory binding abilities; - Specific episodic memory processes; - Implicit learning abilities., Associations between F18-MK6240 regional SUVr or spatial extension measures and CSF biomarker outcomes - Aβ, t-tau, p-tau, Associations between F18-MK6240 regional SUVr or spatial extension measures and Amyloid-PET imaging - Global and regional distribution of amyloid deposition, Associations between F18-MK6240 regional SUVr or spatial extension measures and Neuroimaging outcomes (MRI) - Regional and whole brain volume - Regional cortical thickness - Resting-state functional connectivity - Diffusion-weighted imaging - Task-related brain activity, Associations between F18-MK6240 regional SUVr or spatial extension measures and Blood-derived biomarkers - Amyloid oligomers - Phosphorylated and non-phosphorylated tau species

Related papers

No related papers found yet.

Interventions

DRUGF18-MK6240

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
F18-MK6240 regional SUVr or spatial extension measure differences between patients and controls	—

Secondary

Measure	Time frame
Associations between F18-MK6240 regional SUVr or spatial extension measures and: Cognitive outcomes - Global cognitive measures - Verbal Episodic Memory - Visuospatial/Constructional - Language - Attention/Executive Functioning - Spatial navigational skills; - Face perception and recognition abilities; Specific semantic memory measures; - Short-term memory binding abilities; - Specific episodic memory processes; - Implicit learning abilities., Associations between F18-MK6240 regional SUVr or spatial extension measures and CSF biomarker outcomes - Aβ, t-tau, p-tau, Associations between F18-MK6240 regional SUVr or spatial extension measures and Amyloid-PET imaging - Global and regional distribution of amyloid deposition, Associations between F18-MK6240 regional SUVr or spatial extension measures and Neuroimaging outcomes (MRI) - Regional and whole brain volume - Regional cortical thickness - Resting-state functional connectivity - Diffusion-weighted imaging - Task-related brain activity,	—

Measure

Time frame

Associations between F18-MK6240 regional SUVr or spatial extension measures and: Cognitive outcomes - Global cognitive measures - Verbal Episodic Memory - Visuospatial/Constructional - Language - Attention/Executive Functioning - Spatial navigational skills; - Face perception and recognition abilities; Specific semantic memory measures; - Short-term memory binding abilities; - Specific episodic memory processes; - Implicit learning abilities., Associations between F18-MK6240 regional SUVr or spatial extension measures and CSF biomarker outcomes - Aβ, t-tau, p-tau, Associations between F18-MK6240 regional SUVr or spatial extension measures and Amyloid-PET imaging - Global and regional distribution of amyloid deposition, Associations between F18-MK6240 regional SUVr or spatial extension measures and Neuroimaging outcomes (MRI) - Regional and whole brain volume - Regional cortical thickness - Resting-state functional connectivity - Diffusion-weighted imaging - Task-related brain activity,

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Countries

Belgium

Outcome results

None listed