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A 6-Month, Randomized, Double-Blind Study to Evaluate the Effect of Dapagliflozin on EChOcardiographic Measures of CarDiac StructurE and Function in Patients with Chronic Kidney Disease (DECODE-CKD)

Status
Not yet recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-517040-65-02
Enrollment
260
Registered
2024-10-15
Start date
Unknown
Completion date
Unknown
Last updated
2025-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease

Brief summary

Change in LV mass index assessed by echocardiography at 6 months

Detailed description

Change in LV ejection fraction at 6 months, Change in global longitudinal strain at 6 months, Change in LV end-diastolic volume at 6 months, Change in LV end-systolic volume at 6 months, Change in left atrial volume index at 6 months, Change in creatinine/eGFR at 6 months, Change in UACR at 6 months, Change in haemoglobin at 6 months, Change in proBNP at 6 months, Change in Troponin at 6 months, Change in LV mass at 6 months

Interventions

DRUGThe placebo will be identical in apperance and contains the following ingredients: FDA/E172 Red Iron Oxide
DRUGTitanium dioxide
DRUGHydromellose.
DRUGDAPAGLIFLOZIN

Sponsors

Gentofte Hospital
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Secondary

MeasureTime frame
Change in LV ejection fraction at 6 months, Change in global longitudinal strain at 6 months, Change in LV end-diastolic volume at 6 months, Change in LV end-systolic volume at 6 months, Change in left atrial volume index at 6 months, Change in creatinine/eGFR at 6 months, Change in UACR at 6 months, Change in haemoglobin at 6 months, Change in proBNP at 6 months, Change in Troponin at 6 months, Change in LV mass at 6 months—

Primary

MeasureTime frame
Change in LV mass index assessed by echocardiography at 6 months—

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026