Functional Dyspepsia
Conditions
Brief summary
Duodenal eosinophils before treatment and after 8 weeks of treatment
Detailed description
Gastro-intestinal symptoms of patients, based on the Leuven Postprandial Distress Scale (LPDS) before treatment and after 8 weeks of treatment, Quality of life of patients before treatment and after 8 weeks of treatment, State of anxiety, depression and somatization before treatment and after 8 weeks of treatment, Mucosal permeability, including gene and protein expression of major tight-junction related molecules and cytokines before treatment and after 8 weeks of treatment, Gastric motility by assessing gastric emptying time, gastric sensitivity to distension and gastric accommodation reflex before treatment and after 8 weeks of treatment, The mucosa-associated microbiome before treatment and after 8 weeks of treatment
Interventions
Sponsors
UZ Leuven
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duodenal eosinophils before treatment and after 8 weeks of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastro-intestinal symptoms of patients, based on the Leuven Postprandial Distress Scale (LPDS) before treatment and after 8 weeks of treatment, Quality of life of patients before treatment and after 8 weeks of treatment, State of anxiety, depression and somatization before treatment and after 8 weeks of treatment, Mucosal permeability, including gene and protein expression of major tight-junction related molecules and cytokines before treatment and after 8 weeks of treatment, Gastric motility by assessing gastric emptying time, gastric sensitivity to distension and gastric accommodation reflex before treatment and after 8 weeks of treatment, The mucosa-associated microbiome before treatment and after 8 weeks of treatment | — |
Countries
Belgium
Outcome results
None listed