EEG-MRI Study of the Effect of Methylphenidate on Neural Mechanisms in Adult Patients With ADHD With or Without Mood Disorders: a Randomized Controlled Trial Versus Placebo

Conditions

Attention Deficit Hyperactivity Disorder (ADHD)

Brief summary

Effect of methylphenidate on the task vs. rest in a region defined by its involvement in the cognitive task and its reactivity to methylphenidate. ROI (Region of Interest) analysis to maximize power.

Detailed description

Decrease in rCBF (regional Cerebral Blood Flow) in the methylphenidate condition vs. placebo, in the different groups., Improved cognitive performance on tests of sustained attention, working memory and flexibility following the administration of methylphenidate, in the different groups., Stabilization of the power of the EEG spectrum in the low frequencies (delta (1-4Hz) and theta (4-8Hz)) in the methylphenidate condition vs. placebo., MRI: Interaction group x treatment x task on cerebral activation linked to sustained attention and linked to the inhibition corresponding to each of these tasks., EEG: Group x treatment x task interaction on the amplitude of the XML File Identifier: 0Vmd7NrSRK8JeP+9ISLPaO9Oq+U= Page 14/26 P300 wave linked to sustained attention (P300b) and linked to inhibition (P300a) corresponding to each of these tasks.

Related papers

No related papers found yet.

Interventions

DRUGRITALINE 10 mg

DRUGcomprimé sécable

DRUGFORMULE 515 AP-HP (placebo)- préparation hospitalière

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Effect of methylphenidate on the task vs. rest in a region defined by its involvement in the cognitive task and its reactivity to methylphenidate. ROI (Region of Interest) analysis to maximize power.	—

Secondary

Measure	Time frame
Decrease in rCBF (regional Cerebral Blood Flow) in the methylphenidate condition vs. placebo, in the different groups., Improved cognitive performance on tests of sustained attention, working memory and flexibility following the administration of methylphenidate, in the different groups., Stabilization of the power of the EEG spectrum in the low frequencies (delta (1-4Hz) and theta (4-8Hz)) in the methylphenidate condition vs. placebo., MRI: Interaction group x treatment x task on cerebral activation linked to sustained attention and linked to the inhibition corresponding to each of these tasks., EEG: Group x treatment x task interaction on the amplitude of the XML File Identifier: 0Vmd7NrSRK8JeP+9ISLPaO9Oq+U= Page 14/26 P300 wave linked to sustained attention (P300b) and linked to inhibition (P300a) corresponding to each of these tasks.	—

Measure

Time frame

Decrease in rCBF (regional Cerebral Blood Flow) in the methylphenidate condition vs. placebo, in the different groups., Improved cognitive performance on tests of sustained attention, working memory and flexibility following the administration of methylphenidate, in the different groups., Stabilization of the power of the EEG spectrum in the low frequencies (delta (1-4Hz) and theta (4-8Hz)) in the methylphenidate condition vs. placebo., MRI: Interaction group x treatment x task on cerebral activation linked to sustained attention and linked to the inhibition corresponding to each of these tasks., EEG: Group x treatment x task interaction on the amplitude of the XML File Identifier: 0Vmd7NrSRK8JeP+9ISLPaO9Oq+U= Page 14/26 P300 wave linked to sustained attention (P300b) and linked to inhibition (P300a) corresponding to each of these tasks.

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Countries

France

Outcome results

None listed