Ketoanalogue Supplementation for Muscle Protection in CKD 4 and 5 Patients with Moderately Low Protein Diet

Conditions

kidney disease

Brief summary

Muscle mass index measured by DEXA (appendicular lean mass kg/m²) at 12 months. Appendicular muscle mass is the sum of the lean muscle mass of the upper and lower extremities.

Detailed description

Weight and BMI at 3, 6, 12 months, Concentration of albumin, prealbumin and CRP at 3, 6, 9 and 12 months, Serum lipids and glycemia at 12 months, Skin fold and mid arm muscle circumference, Grip strength measured by dynamometry at 12 months, Muscle performance evaluated by walking speed test over 4 meters at 12 months, Serum Calcium and phosphate at 3, 6, 9 and 12 months, Parathormone at 3, 6, 9 and 12 months, 25OH Vitamin D2 + D3 at 12 months, Bone mineral density measured by DEXA at 12 months, Use and dosage of phosphate binders, Time to renal replacement therapy start (or transplantation?), Estimated GFR using 2012 CKD EPI creatinine and cystatin C equation at 12 months, Proteinuria at 12 months

Related papers

No related papers found yet.

Interventions

DRUGKetosteril Ketoacid film-coated tablets

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Muscle mass index measured by DEXA (appendicular lean mass kg/m²) at 12 months. Appendicular muscle mass is the sum of the lean muscle mass of the upper and lower extremities.	—

Secondary

Measure	Time frame
Weight and BMI at 3, 6, 12 months, Concentration of albumin, prealbumin and CRP at 3, 6, 9 and 12 months, Serum lipids and glycemia at 12 months, Skin fold and mid arm muscle circumference, Grip strength measured by dynamometry at 12 months, Muscle performance evaluated by walking speed test over 4 meters at 12 months, Serum Calcium and phosphate at 3, 6, 9 and 12 months, Parathormone at 3, 6, 9 and 12 months, 25OH Vitamin D2 + D3 at 12 months, Bone mineral density measured by DEXA at 12 months, Use and dosage of phosphate binders, Time to renal replacement therapy start (or transplantation?), Estimated GFR using 2012 CKD EPI creatinine and cystatin C equation at 12 months, Proteinuria at 12 months	—

Measure

Time frame

Weight and BMI at 3, 6, 12 months, Concentration of albumin, prealbumin and CRP at 3, 6, 9 and 12 months, Serum lipids and glycemia at 12 months, Skin fold and mid arm muscle circumference, Grip strength measured by dynamometry at 12 months, Muscle performance evaluated by walking speed test over 4 meters at 12 months, Serum Calcium and phosphate at 3, 6, 9 and 12 months, Parathormone at 3, 6, 9 and 12 months, 25OH Vitamin D2 + D3 at 12 months, Bone mineral density measured by DEXA at 12 months, Use and dosage of phosphate binders, Time to renal replacement therapy start (or transplantation?), Estimated GFR using 2012 CKD EPI creatinine and cystatin C equation at 12 months, Proteinuria at 12 months

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Countries

France

Outcome results

None listed