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A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Impactof Maridebart Cafraglutide on Cardiovascular Outcomes in Participants with Atherosclerotic Cardiovascular Disease and Overweight or Obesity (MARITIME-CV)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-516652-18-00
Acronym
20220196
Enrollment
5564
Registered
2025-10-06
Start date
2025-10-10
Completion date
Unknown
Last updated
2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerotic cardiovascular disease (ASCVD) and obesity or overweight

Brief summary

Time to first occurrence of a composite endpoint consisting of: CV death, myocardial infarction (MI), or ischemic stroke (3-point major adverse cardiac events [3-P MACE]), Time to first occurrence of a composite endpoint consisting of: all-cause death, MI, ischemic stroke, coronary revascularization, or heart failure (HF) event (5-point major adverse cardiac events [5-P MACE])

Detailed description

Time to first occurrence of a composite endpoint consisting of: CV death, MI, ischemic stroke, or HF event, Time to first occurrence of a composite endpoint consisting of: CV death, MI, ischemic stroke or coronary revascularization

Interventions

Sponsors

Amgen Inc.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
Time to first occurrence of a composite endpoint consisting of: CV death, myocardial infarction (MI), or ischemic stroke (3-point major adverse cardiac events [3-P MACE]), Time to first occurrence of a composite endpoint consisting of: all-cause death, MI, ischemic stroke, coronary revascularization, or heart failure (HF) event (5-point major adverse cardiac events [5-P MACE])

Secondary

MeasureTime frame
Time to first occurrence of a composite endpoint consisting of: CV death, MI, ischemic stroke, or HF event, Time to first occurrence of a composite endpoint consisting of: CV death, MI, ischemic stroke or coronary revascularization

Countries

Austria, Belgium, Bulgaria, Czechia, Denmark, Finland, France, Germany, Greece, Hungary, Italy, Netherlands, Poland, Portugal, Romania, Slovakia, Spain, Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026