A randomized trial on Hemodynamic Optimization of cerebral Perfusion after Endovascular therapy in patients with acute ischemic stroke (HOPE study)

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-516642-19-01

Acronym

IIBSP-HOP-2021-01

Enrollment

814

Registered

2024-11-11

Start date

2021-06-16

Completion date

Unknown

Last updated

2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Ischemic Stroke

Brief summary

Direct comparison between the two arms of the trial with respect to mRS score at 90 days after randomization. This will be an intention to treat analysis. The main effect parameter will be the OR of change (shift analysis) in the direction of a better result in the mRS with its 95% confidence interval.

Interventions

DRUGUrapidil Accord 5 mg/ml solución inyectable y para perfusión EFG

DRUGTrandate 5mg/ml Solution for Injection

DRUGFenilefrina Altan 0

DRUG1 mg/ml solución inyectable y para perfusión.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Direct comparison between the two arms of the trial with respect to mRS score at 90 days after randomization. This will be an intention to treat analysis. The main effect parameter will be the OR of change (shift analysis) in the direction of a better result in the mRS with its 95% confidence interval.	—

Countries

Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026