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Impact of microglial activation on synaptic density in Alzheimer’s disease

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-516566-11-00
Acronym
D23-P006
Enrollment
90
Registered
2024-11-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzeihmer disease

Brief summary

The degree of correlation at baseline between [18F]-DPA-714, [18F]-Ro948, and [11C]-UCB-J expressed in SUVr will be assessed with Kendall's Tau test

Detailed description

The multivariate approach of the Mixed Model Repeated Measures (MMRM) will be used to evaluate the longitudinal evolution of clinical and instrumental parameters collected. Analyses will be adjusted for clinical and demographic characteristics at baseline.

Interventions

Sponsors

Groupe Hospitalier Universitaire Paris Psychiatrie Et Neuroscience
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
The degree of correlation at baseline between [18F]-DPA-714, [18F]-Ro948, and [11C]-UCB-J expressed in SUVr will be assessed with Kendall's Tau test

Secondary

MeasureTime frame
The multivariate approach of the Mixed Model Repeated Measures (MMRM) will be used to evaluate the longitudinal evolution of clinical and instrumental parameters collected. Analyses will be adjusted for clinical and demographic characteristics at baseline.

Countries

France

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026