Early Model-Informed Precision Dosing of beta-lactam antibiotics in critically ill children: big solution for small people?

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-516447-12-00

Acronym

MOMENTUM trial

Enrollment

Registered

2024-11-07

Start date

2025-04-30

Completion date

Unknown

Last updated

2025-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic infections

Brief summary

Proportion of subjects reaching the therapeutic target 100% fT>MIC at 48 hours after start of beta-lactam treatment

Detailed description

Proportion of subjects reaching the therapeutic target 100% fT>MIC at 120 hours after start of treatment, Proportion of subjects reaching the therapeutic target 100% fT>MIC within the interval 48 to 72 hours after start of treatment, Hospital length-of-stay

Interventions

DRUGAMOXICILLIN

DRUGPIPERACILLIN AND BETA-LACTAMASE INHIBITOR

DRUGAMOXICILLIN AND BETA-LACTAMASE INHIBITOR

DRUGMEROPENEM

Eligibility

Sex/Gender

All

Age

0 Years to 17 Years

Design outcomes

Primary

Measure	Time frame
Proportion of subjects reaching the therapeutic target 100% fT>MIC at 48 hours after start of beta-lactam treatment	—

Secondary

Measure	Time frame
Proportion of subjects reaching the therapeutic target 100% fT>MIC at 120 hours after start of treatment, Proportion of subjects reaching the therapeutic target 100% fT>MIC within the interval 48 to 72 hours after start of treatment, Hospital length-of-stay	—

Countries

Belgium

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026